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Cortisol Hormone Test (Saliva)

The Saliva Cortisol test is the least invasive way to measure the level of cortisol in the body.  Cortisol is a hormone produced by the adrenal glands and regulated by the hypothalamus, a part of the brain, and the pituitary gland.  Cortisol is a critical hormone that helps to break down fat and protein.  The level of cortisol in the body stimulates liver glucose production and helps to maintain blood pressure and regulate the immune system affecting inflammation.  It also helps us react to physical and emotional stress. Free cortisol, which is unbound to a protein, is found in the urine and in the saliva and cortisol levels normally fluctuate throughout the day, with levels being highest in the morning and lowest after midnight.

High levels of cortisol may be caused by Cushing Syndrome, a relatively rare disorder that could result from taking glucocorticoid-steroids for a prolonged period or an adrenal tumor.

Addison’s disease (primary or secondary) or adrenal insufficiency cause low levels of cortisol and may be a result of an autoimmune response to the adrenal glands or an adrenal tumor.  70% of primary adrenal insufficiency is caused by an autoimmune process that ultimately destroys the adrenal cortex.

Test Details

The Saliva Cortisol Test measures the level of cortisol in your saliva.

Varies depending on age and supplementation.

High results may indicate Cushing syndrome or a tumor or disorder affecting the pituitary or adrenal glands.

Low results may indicate primary or secondary Addison’s disease (or adrenal insufficiency) or a tumor or disorder affecting the pituitary or adrenal glands.

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Am I required to fast?

No, fasting is not required. There are no dietary or medicinal restrictions to take this test.

Is a doctor's order required?

No. You do not need to provide a doctor’s order to get lab testing done at Any Lab Test Now.

Do I need to make an appointment?

No. You can walk in for same day testing. We make it easy for you by offering work-friendly hours.

If I have questions about my tests results who should I contact?

We recommend you share your results with your physician.