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Factor V (Leiden)

A genetic test can be performed to determine whether you have the genetic mutation and whether you have the mutated gene and whether you have one or two mutated genes. This test can be performed in combination with another test option to determine whether your blood is resistant to activated protein C, one of the anti-clotting proteins that help control factor V. This is known as an activated protein C (APC) resistance assay.  Normal results would show that the blood is not resistant to APC and therefore any abnormal blood clots are not likely to be caused by the factor V Leiden mutation.

If your blood is resistant to activated protein C, you likely have a mutation in the factor V gene.  95% of people resistant to activated protein C have the factor V Leiden mutation.  A follow up test to consider is the Factor V (Leiden) DNA Mutation Analysis with Reflex to HR2 Mutation Analysis.

Test Details


  • Activated Protein C Resistance with Reflex to Factor V (Leiden) Mutation
  • Activated Protein C Resistance (APC-R) test or assay
  • Factor V (Leiden) DNA Mutation Analysis with Reflex to HR2 Mutation Analysis

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Am I required to fast?

No, fasting is not required. There are no dietary or medicinal restrictions to take this test.

Is a doctor's order required?

No. You do not need to provide a doctor’s order to get lab testing done at Any Lab Test Now.

Do I need to make an appointment?

No. You can walk in for same day testing. We make it easy for you by offering work-friendly hours.

If I have questions about my tests results who should I contact?

We recommend you share your results with your physician.